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Significance of Palindromic sequences:

  1. Short palindromes serve as recognition sites of DNA for proteins having two-fold symmetry. E.g. Lac repressor proteins, Bacterial restriction enzymes.
  2. Binding of proteins to DNA is due to specific interactions between specific regions of DNA and proteins.
  3. Bacterial restriction enzymes serve as protection against foreign DNA by destroying it. These enzymes are specific for palindromic sequences of double stranded DNA.
  4. Palindromes give structural strength to transcribed RNA by hydrogen bonding in hair-pin loops.
  5. Long palindromic sequences contain genes coding for r-RNA.
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