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  1. This hypothesis was put forward by Emil Fisher in the year 1894.
  2. It is also known as Fischer’s template theory.
  3. Enzymes have distinct active centres or active sites on their surface in which specific type of substrate molecules can bind. These areas of the substrate with which association is done with enzymes are called reactive sites.
  4. This binding of enzyme and substrate is similar to how a key fits into the proper lock.
  5. The enzyme-substrate complex (ES complex) is formed when the enzyme and substrate fit into one another.
  6. This ES complex breaks to release the enzyme and product of biochemical reaction.
  7. The active site of an enzyme is rigid and a pre-shaped template where only a specific substrate can bind.
  8. This model does not give any information about the flexible nature of enzymes.
  9. It totally fails to explain the effect of allosteric modulators.
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