in Principles and process of Biotechnology by

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Replication in eukaryotes takes place in S- phase of cell cycle. Due to large size of DNA in eukaryotes there are many origin of replication. In yeast specific sequences are identified which function like origin of replication. These sequences are known as autonomously replicating sequences (ARS). In mammals and other eukaryotes the sequences of origin of replication are not well-defined due to their complexity.