Deficiency of vitamin B1 inhibits carbohydrate metabolism and leads to accumulation of pyruvate.
- Low Deficiency (Early symptoms)
- Loss of appetite (anorexia)
- Brain depends on Thiamine Pyrophosphate (TPP) for energy, thus leads to mental depression, irritability, fatigue, peripheral neuropathy.
- Moderate Deficiency:
It leads to Wernicke’s encephalopathy (or Wernicke’s-Korsakoff syndrome)
Its symptoms are:
Mental confusion, Ataxia, Ophthalmoplegia commonly seen in chronic alcoholics.
- Severe deficiency
Severe deficiency leads to Beri-beri.
- Dry Beri-beri
- Advanced neuromuscular symptoms.
- Weakness of muscles.
- Wet Beri-beri
- Edema of legs, face, trunk and serious cavities.
- High cardiac output, resulting in heart failure.
- Infantile Beri-beri
- In mothers having thiamine deficiency and giving birth, infant may show infertile beri-beri
- Symptoms are sleeplessness, restlessness, vomiting, convulsions and cardiodilation. Infant may die.